This page is meant for anyone who has suggestions/comments on how I may extend my life expectations. And perhaps someone may benefit from my history. Send any comments to joop.kroes@gmail.com
My colon cancer history
started during a sabbatical in 2009 at UC Davis (California, USA) where an old
fashioned toilet made me look at my slightly red colored stool. Two weeks
later, on October 29, I left a clinic near Sacramento with a clear result from
the colonoscopy: a large mass at 55 cm almost blocking the colon. A few days
later I flew back home and a Hemicolectomy-surgery was carried out in hometown
hospital Rijnstate in Arnhem. A heavy chemo therapy followed in 2010.
Unfortunately in 2011 another surgery was required: Hemihepatectomy to remove 2
metastases in segments 2 and 3. This was carried out in the University Medical
Centre Radboud who was specialized in liver cancer surgery. I stayed there as
patient until today. In 2015 the treatments for my disease went from curative
to palliative and I started receiving systemic chemo therapies.
During the past eleven years
I received about 64 chemo therapies given in 8 different compositions. I
received 2 radiation treatments and underwent more than 30 CT-scans and 4
PET-scans.
An overview of all
treatments during 2009-2020 is given in Table 1.
In 2015 I applied for a
second opinion in NKI/AVL and informed about proton-therapy in Heidelberg
(Germany). Proton-therapy was on option for metastases. NKI suggested
gene-analyses.
In 2009 and 2015 limited
gene-analyses were carried out with a biopsy from 2009 and showed: no mutation
in KRAS and NRAS, wildtype BRAF and RAS, MisMatch Repair (MMR) status is: MSS.
In 2017 a sequencing was
carried out by the Dutch CPCT (https://www.cpct.nl/) using
a biopsy from 2016. This showed: a Tumor Mutational Load of 9, no PDGFRA
amplification, so it seemed unfortunately no option to participate in DRUP
study (https://clinicaltrials.gov/ct2/show/NCT02925234).
I just received a chemo
therapy of Irinotecan, but I think that its efficiency is dropping. So I am soon
going to be in need of alternatives.
Year |
Month |
Treatment |
2009 |
11 |
Hemicolectomy
(left, descending, 6 cm) adenocarcinoma, stage: pT3N1M0 |
2010 |
01 |
adjuvant
chemo: 8x capecitabine oxaliplatin |
2011 |
07 |
Hemihepatectomy. liver metastases resection of segments 2,3 |
2015 |
07 |
stereotactic
radiotherapy 3x18Gy due to growth 2 lung metastases |
2015 |
09 |
progression
of mediastinal and hilar lymphadenopathy |
2015 |
12 |
radiation
pneumonitis, treated with prednisone |
2016 |
05 |
Thoracotomy
right with resection of nodes in mediastinum, hilar station |
2017 |
07 |
PET-CT
shows increase in lung and suspected pericardial metastasis |
2017 |
10 |
2000
ml pericardial fluid drained via puncture |
2017 |
10 |
start
chemo therapy capecitabine-bevacizumab via PICC line |
2018 |
12 |
therapy
pause (low disease load normal CEA) |
2019 |
06 |
therapy
restart with S-1 (Teysuno alternative for Capecitabine) |
2020 |
01 |
therapy
continued with Cetuximab |
2020 |
06 |
Cetuximab
stopped due to increasing metastases in lungs which block trachea |
2020 |
07 |
radiotherapy
8 x 3Gy on lung metastases |
2020 |
08 |
start
chemo therapy Irinotecan |
Geen opmerkingen:
Een reactie posten